United will be aiming to kick off March by getting back to winning ways, following the goalless draw with Watford last time out.
It's the first of three mouth-watering clashes this month, prior to the international break in a couple of weeks' time, with a league fixture against Tottenham Hotspur and a Champions League last-16 second leg versus Atletico Madrid to come.
Sunday's game will be the 189th Manchester derby in history and, here, we've rounded up all the key information that you need...
HOW TO WATCH
The game is set to be broadcast live on Sky Sports in the UK, with coverage starting half an hour before the 16:30 GMT kick-off.