The new boss will lead his team out at the Theatre of Dreams for the first time in the Premier League, in front of the Sky Sports cameras and a full house, as the Reds aim to get the 2022/23 campaign off to a good start.
So how did our previous permanent managers fare in their opening league fixture at the helm?
Let's run through the post-War list...
Sir Matt Busby - Grimsby (H) 2-1, 1946
The great man agreed to join the Reds in February 1945 but did not take over until October due to his army duties.