Diogo Dalot started for Roberto Martinez's men, who had already assured top spot, performing in an interesting role that combined his defensive and attacking talents. However, he moved to centre-back after Georgia went 2-0 ahead, with Cristiano Ronaldo one of the players making way.
Bruno Fernandes, who scored against Turkey in the last match, remained an unused substitute.
Georgia, who have qualified for the knockout stages despite appearing in their first finals, struck a lightning bolt after only 92 seconds. Antonio Silva's sloppy pass was seized upon by Georges Mikautadze, and his ball to Kvicha Kvaratskhelia was ruthlessly finished by the left boot of the Napoli star.