This is the second ankle problem the striker has suffered in recent weeks, after initially being injured early in the February draw with Liverpool, and last month he was forced to withdraw from the England squad.
However, speaking to Sky Sports ahead of the Wolves game, Ole said that Rashford's absence was due to a fresh injury, not a recurrence of the previous one.
“Yeah, he got a knock again, but it’s a different ankle, it’s not the same ankle luckily. He’ll be sorely missed today. Hopefully Rom [Lukaku] can do the job though.
“We tried to get him [Marcus] fit,”added Ole,“but he didn’t make it so, hopefully we can mend him for the next game.