The ex-Netherlands international, who was top scorer when we last won the Premier League title in 2012/13, has spent time at Carrington, with Erik ten Hag and his coaching staff, while learning his new trade.
The 40-year-old has signed for the next two seasons with a side currently 10th in the table as he takes his first step in management.
There is one game remaining this term but he is taking the helm for 2024/25.
Van Persie took up coaching after retiring in 2019 and has been working at another of his former teams in Feyenoord.