It was confirmed on Wednesday night that the Spaniard is definitely out of the match, due to the injury that he sustained while playing for his national team earlier this week.
Romero has already proven himself a more than capable replacement for De Gea during his four years at the club. Impressively, the Argentinian has won 32 of the 46 United games he’s featured in and lost just six of those encounters.
Here, you can look back at five of his best performances as a Red...
ROMERO V MIDTJYLLAND, FEB 2016
Sergio enjoyed a run of Premier League games at the start of his first season with United, but his Europa League bow did not arrive until the new year.