With strength in depth in every position, the Spanish visitors will undoubtedly pose a stiff test. Here are just five of the players that Ole Gunnar Solskjaer's men will need to be wary of going into this important encounter...
MARC-ANDRE TER STEGEN
Now in his fifth season at the club, Marc-Andre ter Stegen has been a model of consistency for the La Liga champions, with an impressive clean sheet record once again this term.
The 26-year-old faces stiff competition for both club and country, with Netherlands’ stopper Jasper Cillessen his number two at the Nou Camp, while ter Stegen acts as understudy to Manuel Neuer for Germany.