Wednesday night’s 19:00 GMT kick-off will be United’s fifth game in the cup, having entered at the third-round stage.
THIRD ROUND: UNITED 4 SCUNTHORPE UNITED 2
Alejandro Garnacho laid down a marker early on in the competition with an acrobatic finish in front of the Stretford End proving the highlight of this match.
Travis Binnion’s side led early on thanks to Sam Mather’s tap-in from a Garnacho pull-back. The lively winger made it two when he controlled Charlie McNeill’s pass before lashing it home while airborne. Scunthorpe got one back before half-time, Harry Lewis finding the net after a goalmouth scramble.