Here, in anticipation of the great occasion, three club journalists recall their memories of United's most recent successes in the prestigious competition for Academy sides - in 1992, 1995 and 2011 - while another contemplates what lies ahead tonight.
1992: UNITED v CRYSTAL PALACE
Adam Marshall
I’m unfortunately old enough to remember seeing players compete in the FA Youth Cup who are now long retired and I always found it fascinating trying to identify any potential stars of the future. The Class of 92’s triumph over Crystal Palace was memorable for Ryan Giggs leading the side when he was already becoming a first-team favourite and I vividly recall watching the following year’s final with Leeds United.