Erik ten Hag is reportedly set to play Jonny Evans in an unusual position when Man United face Brentford at Old Trafford on Saturday.
The under pressure manager will be without five defenders for the Premier League clash as he seeks to avoid a third straight defeat at home in the top flight.
Left-backs Tyrell Malacia and Luke Shaw will miss the match, as will centre-backs Harry Maguire and Leny Yoro.
Right-back Noussair Mazraoui will also be sidelined until November after he underwent a minor heart procedure following complaints of palpitations.