The sides kick off at Old Trafford at 20:15 GMT, with the match being streamed live on Amazon Prime.
After the disappointing performance, and 1-0 defeat at Newcastle United, the boss will be demanding an improved display under the lights in M16, as we look to get back on track in a push for the UEFA Champions League slots.
Luke Shaw has shifted to left-back, with Victor Lindelof one of four changes to the line-up, as Aaron Wan-Bissaka makes way. On-loan midfielder Sofyan Amrabat replaces Kobbie Mainoo in the engine room, while Antony and Rasmus Hojlund both start, after coming on in the second half at St James' Park.