Steve Cooper's side host United at The City Ground this evening (Wednesday), with the second leg taking place at Old Trafford next week.
Despite using Martin Dubravka - now back at Newcastle United - and Tom Heaton in goal in the previous rounds, Ten Hag has opted to reinstate David De Gea between the sticks for the Reds.
Victor Lindelof partners Lisandro Martinez at the heart of our defence while there is a change in midfield too, with Casemriro returning after serving his one-match suspension for the narrow 3-2 loss at Arsenal on Sunday.
Scott McTominay, who replaced the Brazilian against the Gunners, is on the substitutes' bench, which also features youngsters Brandon Williams, Kobbie Mainoo, Alejandro Garnacho, Anthony Elanga and Facundo Pellistri.