The Manchester derby is the standout fixture in the fourth round of the EFL Cup after United were drawn against local rivals City.
The match will take place at Old Trafford on Wednesday 26 October (kick-off 20:00 BST) which will be sandwiched between two Premier League games against Chelsea (away) and Burnley (home).
Jose Mourinho's men secured a place in the pot following a comfortable 3-1 win over Northampton Town at Sixfields Stadium thanks to goals from Michael Carrick, Ander Herrera and Marcus Rashford. City qualified for the next round with a 2-1 triumph over Swansea City at the Liberty Stadium.