The 33-year-old full-back is set to serve a one-match ban in the competition after picking up a second yellow card of this season’s competition, in the fifth-round victory at Chelsea.
Diogo Dalot is arguably the favourite to take his place at right-back, with Antonio Valencia and Matteo Darmian both injured, although Eric Bailly did play in that position at Paris Saint-Germain this month. Phil Jones has not played since the Premier League win at Fulham on 9 February due to illness.
Meanwhile, further up the pitch, Chilean forward Alexis Sanchez is expected to be unavailable with the injury that he suffered in the recent victory over Southampton at Old Trafford on 2 March.