The Reds have had only one fixture in the division since the turn of the year, the 2-2 draw with Tottenham, but start February with a tough clash against Gary O'Neil's in-form side.
This round of games is a repeat of the opening weekend of the campaign and victory would complete the double over the men from Molineux, following the 1-0 win at Old Trafford in August, courtesy of Raphael Varane's goal.
Both teams have progressed to the Emirates FA Cup fifth round and Erik ten Hag used the tie at Newport County to reintroduce several players after injury.