The Reds are now under pressure for a top-four spot, after losing at Brighton & Hove Albion and West Ham United, but have time this week to prepare at Carrington for the 15:00 BST kick-off.
Three points against Julen Lopetegui's men would get United back on course for a place in next season's Champions League and there could be a return for Alejandro Garnacho. The 18-year-old has been out since March's draw against Southampton with an ankle injury.
The winger was an unused substitute at the London Stadium on Sunday after being recalled to the matchday squad.