Remarkably, it's our sixth straight fixture against Spanish opposition in this season's competition - we've already beaten Real Sociedad (in the final game of the group stages) followed by both Barcelona and Real Betis over two legs. All three of those sides are above Sevilla in La Liga at present.
Erik ten Hag and his men will be hoping for a repeat of the first leg against Sevilla's city rivals Betis, who were vanquished 4-1 at Old Trafford a month ago.
Marcus Rashford scored the opener that night but he is a doubt for this game, after being substituted with a groin problem during Saturday's 2-0 victory over Everton.