Ahead of the tie in the Moldovan capital of Chisinau, the Reds will be focused on bouncing back from the defeat in our opening match of the competition to Real Sociedad.
Manager Erik ten Hag rested Raphael Varane, Scott McTominay and Marcus Rashford for the 1-0 loss, while Lisandro Martinez, Bruno Fernandes and Jadon Sancho were among those to come off the bench.
Luke Shaw has been absent of late but was pictured in training at Carrington on Monday, while Anthony Martial has remained sidelined since being injured in the win over Liverpool. Donny van de Beek and Facundo Pellistri have also been out.