Leny Yoro returned from a short lay-off to start in defence as United lost 1-0 to Nottingham Forest on Tuesday night, despite the Reds dominating possession and creating a number of chances.
Harry Maguire and Mason Mount also came off the bench, with both agonisingly close to scoring an equaliser, to promote their claims to play at the weekend.
Altay Bayindir returned to the fray, as an unused substitute, and the squad is looking in decent shape, although Jonny Evans, Ayden Heaven, Kobbie Mainoo and Amad are still battling to regain fitness, and Lisandro Martinez is ruled out for the remainder of the season.