The Reds have two games in hand on Spurs, who replaced interim manager Cristian Stellini with Ryan Mason on Monday, after a 6-1 defeat at Newcastle United at the weekend.
The Magpies moved above us into third place in the table, on goal difference, on the back of that resounding victory.
So the stakes are high for the 20:15 BST kick-off, as we look to extend our unbeaten run at the Tottenham Hotspur Stadium to four games, after two wins and a draw there.
Of course, fans will be anxiously awaiting news on the prognosis for Bruno Fernandes, after he clearly sustained a knock in the Emirates FA Cup semi-final against Brighton & Hove Albion on Sunday, and was substituted in the 101st minute, with Wout Weghorst taking his place.