Luke Shaw must be considered a doubt to feature after being withdrawn in the first half of the 2-1 victory at Luton Town.
The left-back had also only managed the opening 45 minutes of the previous game, away to Aston Villa, and manager Erik ten Hag admitted: "[It's] clear, when you come off, it doesn't look great."
Victor Lindelof deputised in the position, for the second game running, while Sofyan Amrabat came off the bench to perform in midfield but could be another option in the role.
Aaron Wan-Bissaka has been sidelined of late, which is unfortunate as any return for the defender would open up more possibilities, with either he or in-form Diogo Dalot capable of switching flanks.