The Reds are looking to take a lead to the Italian capital next week with Thursday's 20:00 BST kick-off setting up a likely reunion with Chris Smalling and Henrikh Mkhitaryan, who won the trophy with us in 2017.
After Paul Pogba and Edinson Cavani started the draw at Leeds United on the bench, it will be interesting to see which XI Ole Gunnar Solskjaer opts for.
David De Gea played both legs against Granada in the previous round, while Dean Henderson started again in the Premier League, keeping another clean sheet at Elland Road.