Saturday's 15:00 BST kick-off presents an opportunity to record a third successive win in all competitions and build on consecutive clean sheets for Andre Onana and his defenders.
There were numerous positives in the cup victory that has set up a repeat of last year's final with Newcastle United in round four, including Mason Mount making his third competitive appearance for the club and notching his first assist, for Casemiro's unstoppable header.
Although withdrawn at half-time, the manager explained that was a planned move and hopefully the England international will be available to start again.
Raphael Varane and Harry Maguire started, to push their claims for a place at the heart of the defence, while Sofyan Amrabat certainly made an excellent first impression on the Old Trafford crowd with his aggression and quallity.