The 12:30 BST kick-off provides Ole Gunnar Solskjaer's team with the chance to re-assert ourselves in the Premier League title race, setting a marker for rivals who play later in the weekend.
Both United and Everton have claimed 13 points thus far, two of five teams to currently sit on that total, all of whom trail top-of-the-league Liverpool who have 14 points to their name.
While Everton have had a week's rest since their 2-0 win against Norwich City, United go into this one off the back of a Wednesday night fixture in the UEFA Champions League.