The Reds closed the gap on Arsenal (eight points) and Manchester City (three points) with the weekend win over Crystal Palace and can make up further ground with victory over the Yorkshiremen, who parted company with manager Jesse Marsch on Monday.
The rearranged game is set to be the first one missed by Casemiro if his three-match suspension for the red card on Saturday is confirmed.
With Scott McTominay joining Christian Eriksen and Donny van de Beek on the sidelines, it does leave Erik ten Hag short of midfield options, if the Scotland international is not fit to play.