Wednesday's 20:00 GMT kick-off presents an opportunity to set things up nicely for the second leg at Old Trafford at the start of next month.
Erik ten Hag will be looking for his side to refocus, after costly late goals against Crystal Palace and Arsenal, and can welcome Casemiro back into the fold, after the influential midfielder missed the 3-2 defeat at the Emirates Stadium due to a one-match suspension.
Scott McTominay replaced Casemiro at the weekend, in the only change to the starting line-up at Selhurst Park.
We await any updates on Diogo Dalot and Anthony Martial, who were both unavailable for the game with the Gunners due to injury.