Ralf Rangnick's men will look to progress in the competition after clearing the first hurdle of beating Aston Villa but the Championship side have been in good form since Chris Wilder took charge.
The game is the first of the fourth-round matches taking place across the weekend and offers an early opportunity to book a place in the draw.
Alex Telles, Fred (both Brazil) and Edinson Cavani (Uruguay) have been in World Cup qualifying action for their countries, with Edi scoring an overhead kick in his side's 4-1 victory over Venezuela. With our game being moved, it may affect their ability to start at Old Trafford but Rangnick will provide an update in Thursday's press conference.