There's been change aplenty at both clubs during that time, and we approach Saturday's match with optimism and excitement at the start of our new era.
Ahead of another meeting in the capital, find out how Erik ten Hag and Guardiola's respective squads are taking shape...
Further first-team members Luke Shaw, Kobbie Mainoo, Lisandro Martinez and Facundo Pellistri came back to Carrington earlier this week ahead of the new campaign, following Bruno Fernandes, Diogo Dalot, Alejandro Garnacho, Altay Bayindir and Joshua Zirkzee's respective returns last week.
This contingent further bolsters Ten Hag's ranks, with the Reds having concluded our pre-season tour of the USA at the weekend.