The Reds got back on track, thanks to a brace from Scott McTominay, despite Cole Palmer's effort for the visitors.
The games keep coming thick and fast in this busy month but Jonny Evans was back in the squad, as an unused substitute, after recovering from injury.
Antony and Rasmus Hojlund started and pressed from the outset, while Luke Shaw operated at left-back in the first half before switching to the middle after the interval, when Sergio Reguilon replaced Victor Lindelof.
Sofyan Amrabat performed well in the engine room, after being drafted in for Kobbie Mainoo, while there are a number of attacking options, with Marcus Rashford coming on during the closing stages of the win over the Blues.