The boss is set to use the competition to provide game-time for valuable members of his squad as the Reds take on David Moyes's men for the second time in quick succession, following Sunday's incredible 2-1 victory at the London Stadium.
David De Gea's injury-time penalty save from Mark Noble preserved the lead, obtained after goals by Cristiano Ronaldo and Jesse Lingard overturned Said Benrahma's deflected opener.
The manager has already suggested Lingard will start the game after the England international netted in consecutive Premier League games and will be itching for another opportunity to impress against his former loan club.