The Reds approach the 17.55 GMT kick-off on the back of a brilliant 2-0 win at Manchester City over the weekend, while Milan remain in contention for the Scudetto after victory at Hellas Verona.
The visit of a European superpower is one that will be sorely missed by the fans, who cannot attend the tie due to the ongoing COVID-19 restrictions, and it will present another stern challenge for Ole Gunnar Solskjaer's men following the elimination of Real Sociedad in the previous round.
Marcus Rashford suffered an ankle injury during the Manchester derby and we await an update from the manager on the extent of the England international's problem when he is on media duties on Wednesday afternoon, around 13:30 GMT.