Between them, the great Scotsmen won 18 league titles, seven FA Cups and ensured United were European champions on three separate occasions.
Of course, both men built all-conquering sides during their extended spells in charge at Old Trafford, and as part of our Dream United Team series, we’re asking: which team would come out on top in a six-a-side game?
We’re certainly not spoiled for choice in either side and, after reading through both line-ups, be sure to vote for which team you think would win.
Busby-era side (selected by Ivan Ponting, freelance journalist and author)
1: Harry Gregg
2: Johnny Carey
3: Duncan Edwards
4: Bobby Charlton
5: George Best
6: Denis Law