Club captain Maguire has been absent since being hurt during England's 3-3 draw with Germany, in the UEFA Nations League tie at Wembley, on 26 September.
It is not known whether Saturday's game at Chelsea will come too soon for the 29-year-old, who scored his first league goal for the Reds in a win at Stamford Bridge in February 2020, with a bullet header.
We expect manager Erik ten Hag to provide an update when he addresses the media at Friday's press conference, which will be available to watch on our official club channels from 11:45 BST.