The club legend has been named in Erik ten Hag’s line-up at Old Trafford and, barring any injury in the warm-up, he will play his 510th match as a Red.
That is the same tally that the late Joe Spence registered during his 14 years at the club between 1919 and 1933, during which time, he also scored 168 goals.
De Gea could well move into 10th position outright on Friday night when United welcome Everton to the Theatre of Dreams in the Emirates FA Cup third round.
This latest landmark is a huge achievement and one that should not be underestimated, particularly when you consider the iconic names who populate the list.