The 32-year-old joined the club from Atletico Madrid in 2011, making his league debut in a 2-1 win at West Brom.
His 50th appearance came just two years later, and the Spaniard celebrated it with a clean sheet; a 1-0 win at against Reading in March 2013, with Wayne Rooney as the sole goalscorer.
De Gea hit a century of appearances for the club on the 27th September 2014 in a 2-1 win against West Ham, with Robin van Persie and Rooney, again, on the scoresheet.
The Spaniard's 250th Premier League appearance came at the Vitality Stadium, as Manchester United ran out 2-1 victors against Bournemouth courtesy of goals from Anthony Martial and Marcus Rashford.