The tie will kick off at 19:00 GMT and entry at Leigh Sports Village will be free to all supporters.
Neil Ryan’s side reached this stage of the competition after knocking out holders Chelsea last month, as Mason Greenwood scored a hat-trick in a thrilling 4-3 win for the young Reds.
The club’s Head of Academy, Nicky Butt, recently spoke of the importance of the FA Youth Cup in an interview with United Review after that outstanding victory over Chelsea on 17 December.
“The FA Youth Cup is massive, going back to the Busby Babes and when we won it in 1992,” said Butt.