The Reds drew the Foxes at home in the fourth round of the competition after our 7-0 victory over Barnsley, and the match will take place at 19:45 GMT at Old Trafford.
The match will be shown in the UK, as part of the tiese at this stage on offer across Sky Sports +.
The game is set to be the final one for the Reds in a busy October, where we will play six matches across three different competitions.
The Foxes squeezed past League Two outfit Walsall in the third round, via a penalty shootout, after being held to a 0-0 draw at the Bescot Stadium.