The game is sure to attract a massive television audience as it is being screened live in the UK on BBC One, with kick-off at 17:00 GMT.
It represents a second meeting between the two giant clubs in consecutive weekends, with the Premier League clash at Anfield taking place this Sunday.
The match is a reward for the Reds' 1-0 victory over Championship club Watford in the previous round, while Liverpool overcame a much-changed Aston Villa side.
Clearly the tie of the round, it should be another titanic tussle between Ole Gunnar Solskjaer's men and Jurgen Klopp's team.