Marc Skinner's Reds will round off the league campaign with a blockbuster clash away to Renee Slegers' Gunners, which will be played at the Emirates Stadium.
It will get under way at the same time as the other five matches in the league, at 12:30 BST on Saturday 10 May.
The final day was initially slated to be on Sunday 11 May, but has been brought forward with confirmation of the full schedule.
Elsewhere in the capital, current league leaders Chelsea host Liverpool while, back in Manchester, City are due to face Crystal Palace at the Joie Stadium.