Erik ten Hag has selected defenders Harry Amass and Habeeb Ogunneye for the Istanbul encounter, along with their Under-21s team-mate, striker Ethan Wheatley.
The youngsters will certainly benefit by being involved as the Reds look to get more Europa League points on the board, when meeting Jose Mourinho's Turkish Super Lig side.
Jonny Evans, whose participation had been flagged as a question mark by Ten Hag this week, is missing after sustaining a knock in the 2-1 victory over Brentford. However, Matthijs de Ligt and Casemiro are both fit and ready to feature.
Other absentees include Harry Maguire, Tyrell Malacia, Luke Shaw, Leny Yoro, Kobbie Mainoo and Mason Mount.