Ruben Amorim's group is bolstered by the return of Victor Lindelof and Toby Collyer, who were pictured in training at Carrington earlier today, with both included.
Jonny Evans and Luke Shaw will not make the journey, as United embark on our third European away trip of the season.
Hoping to extend our unbeaten run in the Europa League, the Reds are currently 12th in the group-stage table after five games played.
Amorim has a healthy squad to choose from in Plzen, with six forward options available to the boss which include Rasmus Hojlund, Marcus Rashford and Joshua Zirkzee.