Ruben Amorim revealed on Wednesday that he would select Tyrell Malacia from the off, and the Netherlands international will play his third game since returning from a long-term knee injury, at the Doosan Arena.
Malacia is one of five players introduced to the line-up after Saturday's 3-2 home defeat by Nottingham Forest, with Noussair Mazraoui also brought into the backline.
Whether the Morocco international is fielded as a central defender or a wing-back remains to be seen, but Diogo Dalot retains his place in the XI so there are options.
Casemiro has also been included in the XI, as have Marcus Rashford and Joshua Zirkzee following cameos as substitutes at the weekend.