The midfielder has made six appearances as a substitute since returning from a long-term spell on the sidelines in March, and is included in Erik ten Hag's XI tonight for the first time since 1 November.
Mount replaces captain Bruno Fernandes, who misses the 20:00 BST kick-off at Selhurst Park completely, while Jonny Evans is deemed fit enough to replace the injured Harry Maguire at centre-back.
Andre Onana starts in goal, behind a defence which will be flanked by full-backs Diogo Dalot and Aaron Wan-Bissaka. Evans, back from a muscle issue that he sustained during last month's trip to Chelsea, will partner Casemiro in the centre, with the Brazilian set to play deeper than his customary midfield role once again.