Having missed last weekend's narrow defeat at Tottenham Hotspur, midfielder Manuel Ugarte comes straight back into the starting XI, with Alejandro Garnacho dropping to the bench.
Christian Eriksen and Leny Yoro were also absent for last Sunday's trip to the capital, due to illness, but have recovered to be named among the substitutes for the 12:30 GMT kick-off.
With the look of the line-up similar to last week, Andre Onana continues in goal, behind an expected three-man defence of Matthijs de Ligt, Harry Maguire and Noussair Mazraoui.
Diogo Dalot and Patrick Dorgu should be the wing-backs, while the incoming Ugarte will likely go into central midfield alongside Casemiro.