New Reds signing Patrick Dorgu is set to make his full United debut after arriving from Lecce in the January transfer window. On the bench, fellow new recruit Ayden Heaven takes a place.
Altay Bayindir has appeared for Amorim's side in previous cup meetings but was ruled out by the head coach earlier this week, with Andre Onana retaining his place in goal.
Elsewhere, Rasmus Hojlund comes in for Alejandro Garnacho in attack, with the rest of the side unchanged from our 2-0 defeat to Palace last weekend.
THE TEAMS
United: Onana; Yoro, Maguire, Mazraoui; Dalot, Ugarte, Fernandes, Dorgu; Amad, Mainoo; Hojlund.