The Reds beat Real Sociedad 4-1 (5-2 on aggregate) in Thursday's round-of-16 second leg and had captain Bruno Fernandes to thank, as he struck a hat-trick at Old Trafford.
Diogo Dalot also scored in the five-goal thriller, after Ruben Amorim's side had fallen behind to Mikel Oyarzabal's 10th-minute spot-kick.
We'll play Lyon - who thrashed FCSB in their last-16 tie - in France first, on Thursday 10 April, with the return in M16 seven days later. Kick-off times will be confirmed in due course.
Former Red Nemanja Matic plays for the French club, who are currently sixth in the Ligue Un table.