Diogo Dalot has returned to the starting XI at right-back, replacing Aaron Wan-Bissaka, who was preferred last weekend at Everton.
In midfield, Paul Pogba and Jesse Lingard are both handed starts in place of the injured Fred and Nemanja Matic, who is on the bench.
Marcus Rashford drops to the bench in place of Anthony Elanga, while Cristiano Ronaldo leads the line once more.
Eric Bailly is back on the bench, alongside youngsters Hannibal and Alejandro Garnacho.
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