Our late, late match winner in the 2-1 victory against the Spaniards, Cristiano Ronaldo, has been rested and is on the bench against Rafa Benitez's side.
Into the XI come Aaron Wan-Bissaka, Luke Shaw, Fred, Anthony Martial and Edinson Cavani.
Paul Pogba and Jadon Sancho join Ronaldo amongst the subs after starting against Villarreal.
LINE-UP
United: De Gea, Wan-Bissaka, Lindelof, Varane, Shaw, Fred , McTominay, Greenwood, Fernandes (c), Martial, Cavani.
Subs: Henderson, Bailly, Alex Telles, Pogba, Lingard, Matic, van de Beek, Ronaldo, Sancho.