Here's the side selected by Ole Gunnar Solskjaer and the nine substitutes, of which he can use five - or six if the score is level after 90 minutes and the game goes into extra-time:
United: De Gea; Wan-Bissaka, Lindelof, Bailly, Maguire, Williams; Matic, Fred, Bruno Fernandes; James, Rashford.
Substitutes: Romero, Fosu-Mensah, Andreas, McTominay, Pogba, Mata, Greenwood, Ighalo, Martial.
Meanwhile, Frank Lampard has picked the following line-up:
Chelsea: Caballero, Azpilicueta, Rudiger, Zouma, Alonso, Willian, Jorginho, Kovacic, Mount, James, Giroud.
Substitutes: Kepa, Christensen, Abraham, Pedro, Loftus-Cheek, Hudson-Odoi, Pulisic, Tomori, Emerson.