After some speculation about when the fixture in west London would take place, it has now been scheduled for Wednesday 30 October at 20:05 BST.
The highly anticipated match at Stamford Bridge will be broadcast on Sky Sports in the UK. Liverpool's tie against Arsenal will also be shown live on that evening, at the earlier time of 19:30 BST.
United will no doubt feel confident about beating Chelsea, after securing an impressive 4-0 win over the Blues in their opening match of the Premier League season back in August.
Ole Gunnar Solskjaer’s Reds also won at Stamford Bridge in last season’s Emirates FA Cup, securing an excellent 2-0 win over the Blues in the fifth round.